Frequency of Interferon-Resistance Conferring Substitutions in Amino Acid Positions 70 and 91 of Core Protein of the Russian HCV 1b Isolates Analyzed in the T-Cell Epitopic Context
Table 1
Frequency of occurrence of substitutions at amino acid positions 70 and 91 of the nucleocapsid (core) protein of HCV genotypes 1a, 1b, and 3a in different population groups (in %).
HCV genotype
Substitutions
Geographical variation in % of sequences variants in HCV of different genotypes
Russia
Europe
Asia
USA
Total
1a
nn samples
Q70
3.4
0.7
0
1.7
1.5
H70
0
0
0
0.1
0.1
M91
0
0
0
0
0
Both
0
0
0
0
0
None
96.6
99.3
100
98.2
98.4
1b
nn samples
Q70
27.0
17.7
31.3
59.6
32.4
H70
4.2
0.3
2.7
3.2
2.3
M91
80.4
85.8
43.8
86.2
74.9
Both
27.5
15.5
16.1
54.6
27.0
None
15.9
11.7
38.4
5.5
17.4
3a
nn samples
Q70
2.9
7.1
9.8
0
5.3
H70
0
0
0
0
0
M91
0.6
0
0
0
0.3
Both
0
0
0
0
0
None
96.5
92.9
90.2
100
94.4
Substitutions in both aa 70 and 91; no substitutions.
