Journal of Immunology Research / 2018 / Article / Tab 1

Research Article

Frequency of Interferon-Resistance Conferring Substitutions in Amino Acid Positions 70 and 91 of Core Protein of the Russian HCV 1b Isolates Analyzed in the T-Cell Epitopic Context

Table 1

Frequency of occurrence of substitutions at amino acid positions 70 and 91 of the nucleocapsid (core) protein of HCV genotypes 1a, 1b, and 3a in different population groups (in %).

HCV genotypeSubstitutionsGeographical variation in % of sequences variants in HCV of different genotypes
RussiaEuropeAsiaUSATotal

1ann samples
Q703.40.701.71.5
H700000.10.1
M9100000
Both00000
None96.699.310098.298.4
1bnn samples
Q7027.017.731.359.632.4
H704.20.32.73.22.3
M9180.485.843.886.274.9
Both27.515.516.154.627.0
None15.911.738.45.517.4
3ann samples
Q702.97.19.805.3
H7000000
M910.60000.3
Both00000
None96.592.990.210094.4

Substitutions in both aa 70 and 91; no substitutions.