NF-κB-94ins/del ATTG Genotype Contributes to the Susceptibility and Imbalanced Th17 Cells in Patients with Immune Thrombocytopenia

Figure 2

(a) Significantly lower NF-κB mRNA levels were found in ITP compared with controls (). (b) NF-κB expression levels in ITP patients correlated with NF-κB-94ins/del ATTG genotype status. (c) The expression of NLRP3 was also found significantly different in ITP patients with the WW genotype (median 0.023), WD genotype (median 0.011), and DD genotype (median 0.013, ). (d, e) However, it showed no difference in IL-1β or IL-18 mRNA expression among the three genotypes.

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