Research Article
NF-κB-94ins/del ATTG Genotype Contributes to the Susceptibility and Imbalanced Th17 Cells in Patients with Immune Thrombocytopenia
Table 3
Genotype and allele distribution of NLRP3 gene polymorphisms.
| | Polymorphisms | ITP (%) | Controls (%) | OR (95% CI) | value |
| | NF-κB-94ins/delATTG | | | | | | Genotype | | | | | | WW | 179 (44.42) | 101 (30.06) | | | | WD | 146 (36.23) | 165 (49.11) | 2.003 (1.440–2.787) | 0 | | DD | 78 (19.35) | 70 (20.83) | 1.591 (1.061–1.368) | 0.024 | | Allele | | | | | | W | 504 (62.53) | 367 (54.61) | | | | D | 302 (37.47) | 305 (45.39) | 1.387 (1.126–1.708) | 0.002 | | CARD8 (rs2043211) | | | | | | Genotype | | | | | | AA | 98 (24.32) | 102 (30.36) | | | | AT | 206 (51.12) | 152 (45.24) | 0.709 (0.501–1.004) | 0.052 | | TT | 99 (24.56) | 82 (24.40) | 0.796 (0.532–1.191) | 0.267 | | Allele | | | | | | A | 402 (49.88) | 356 (52.98) | | | | T | 404 (50.12) | 316 (47.02) | 0.883 (0.720–1.084) | 0.235 | | IL-18 (rs1946518) | | | | | | Genotype | | | | | | GG | 123 (30.52) | 90 (26.79) | | | | GT | 184 (45.66) | 175 (52.08) | 1.3 (0.924–1.829) | 0.132 | | TT | 96 (23.82) | 71 (21.13) | 1.011 (0.671–1.523) | 0.959 | | Allele | | | | | | G | 430 (53.35) | 355 (52.83) | | | | T | 376 (46.65) | 317 (47.17) | 1.021 (0.832–1.254) | 0.841 | | IL-1β (rs16944) | | | | | | Genotype | | | | | | GG | 121 (30.02) | 81 (24.11) | | | | GA | 183 (45.41) | 167 (49.7) | 1.363 (0.960–1.936) | 0.083 | | AA | 99 (24.57) | 88 (26.19) | 1.328 (0.888–1.985) | 0.166 | | Allele | | | | | | G | 425 (52.73) | 329 (48.96) | | | | A | 381 (47.27) | 343 (51.04) | 1.163 (0.947–1.427) | 0.149 | | NLRP3 (rs35829419) | | | | | | Genotype | | | | | | AA | 0 (0) | 0 (0) | | | | CA | 0 (0) | 0 (0) | | | | CC | 403 (100) | 336 (100) | | | | Allele | | | | | | A | 0 (0) | 0 (0) | | | | C | 806 (100) | 672 (100) | | |
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