Hepatitis B Vaccination Induced TNF-α- and IL-2-Producing T Cell Responses in HIV− Healthy Individuals Higher than in HIV+ Individuals Who Received the Same Vaccination Regimen

Figure 3

Fold increases in cytokine-producing and CD107a-expressing memory T cells in healthy control individuals. Fold increases in TNF-α, IFN-γ, IL-2, and IL-10 cytokine production, and CD107a expression, by memory CD4+ (a–e) and CD8+ (f–j) T cells in response to recombinant HBsAg by HIV− healthy individuals who were vaccinated with the standard dose regimen, compared before in vivo vaccination on day 0 (D0), and at day 7 (D7), day 28 (D28), month 6 (6m), month 7 (7m), and month 12 (12m) after vaccination. Medians are represented by thick, wide horizontal bars; 25–75% interquartile ranges are represented by thin, narrow bars. All values < 0.05 were considered statistically significant. “” and “” stand for and , respectively.