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Journal of Immunology Research
Volume 2018 (2018), Article ID 9324357, 11 pages
https://doi.org/10.1155/2018/9324357
Review Article

The Role of Flavonoids in Inhibiting Th17 Responses in Inflammatory Arthritis

1Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 40500 Larissa, Greece
2Division of Liver Transplantation and Mucosal Biology, King’s College London School of Medicine, Denmark Hill Campus, London SE5 9RS, UK

Correspondence should be addressed to Dimitrios P. Bogdanos; rg.htu.dem@sonadgob

Received 23 October 2017; Accepted 3 January 2018; Published 5 March 2018

Academic Editor: Lifei Hou

Copyright © 2018 Dimitra Kelepouri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Flavonoids have been considered powerful anti-inflammatory agents, and their exact immunomodulatory action as therapeutic agents in autoimmune diseases has started to emerge. Their role in the manipulation of immunoregulation is less understood. Several studies attempted to investigate the role of various flavonoids mainly in experimental models of autoimmune diseases, especially in the context of their potential effect on the increase of regulatory T cells (Tregs) and their ability to stimulate an overexpression of anti-inflammatory cytokines, in particular that of IL-10. The emergence of IL-17, a cytokine largely produced by Th17 cells, as a powerful proinflammatory stimulus which attenuates the induction of Tregs has prompted a series of studies investigating the role of flavonoids on Th17 cells in experimental models as well as human autoimmune diseases. This review thoroughly discusses accumulated data on the role of flavonoids on Th17 in rheumatoid arthritis and experimental autoimmune arthritis.