The Role of Flavonoids in Inhibiting Th17 Responses in Inflammatory Arthritis

Table 1

Main features of animal models of rheumatoid arthritis regarding proinflammatory cytokines, including IL-17.

Animal models	IL-17	IL-23	IFN-γ	TNF-α	IL-6	References
CIA mice	+	+	++	+++	++	[27, 29, 30, 105]
SKG mice	++	++	+	+	+	[32–35]
K/BxN mice	++	+/−	++	+	+/−	[15, 37, 38]
TNF-α transgenic mice	+	+	+	+++	+	[39, 40, 43, 44]
gp130 F759/F759 knock-in mice	++	+	+	+	++	[45, 46]
IL-1 RA knockout mice	++	++	+	+	+	[47, 49–51]

⁺Low expression, ⁺⁺moderate expression, and ⁺⁺⁺high expression.