Journal of Immunology Research / 2018 / Article / Tab 4

Research Article

Immune Response to Rotavirus and Gluten Sensitivity

Table 4

Selection of DEGs in NCGS that are also modulated in human T84 cells after stimulation with anti-VP7 rotavirus peptide antibodies.

Gene symbolAccession numberGene titleFC NCGS PBCsFC T84 treated cells

Apoptosis
SOCS3NM_003955Suppressor of cytokine signaling 31.832.75
ANXA6NM_001155Annexin A61.572.72
SOS2NM_006939Son of sevenless homolog 2 (Drosophila)1.901.75
DEDDAF064605Death effector domain containing1.781.47
Immune response
IFNA17NM_021268Interferon, alpha 171.591.56
IL6RS72848Interleukin 6 receptor1.792.76
IRF5NM_03264335Interferon regulatory factor 51.521.52
CD84AF054818CD84 molecule2.553.40
Inflammatory response
IL1BNM_000576Interleukin 1, beta1.521.80
IL24NM_006850Interleukin 242.842.19
IL2RAK03122Interleukin 2 receptor, alpha1.861.48
S100A8AW238654S100 calcium-binding protein A83.651.86
Cell proliferation
FGFR2NM_022975Fibroblast growth factor receptor 21.562.89
RAC2NM_002872Ras-related C3 botulinum toxin substrate 22.311.53
CDK2AB012305Cyclin-dependent kinase 21.631.78
DLG1AL121981Discs, large homolog 1 (Drosophila)1.571.74
Cell differentiation
GAS7BC006454Growth arrest-specific 7−2.03−1.90
SRD5A1NM_001047Steroid-5-alpha-reductase, alpha polypeptide 1−2.53−1.54
VAMP5NM_006634Vesicle-associated membrane protein 5−1.71−1.58
ZAKNM_016653Sterile alpha motif and leucine zipper containing kinase AZK−2.02−1.71
Cell–cell junctions
VCLNM_014000Vinculin−1.68−1.56
CTNND1NM_001331Catenin (cadherin-associated protein), delta 1−2.33−1.75
CTNNA1NM_001903Catenin (cadherin-associated protein), alpha 1, 102 kDa−2.49−1.57
COL8A2NM_005202Collagen, type VIII, alpha 2−1.62−1.64
Metalloproteases
ADAM8AI814527ADAM metallopeptidase domain 81.941.57
ADAM9NM_003816ADAM metallopeptidase domain 92.811.48
ADAM17AI797833ADAM metallopeptidase domain 171.511.56
Receptors and signal transduction
IL2RAK03122Interleukin 2 receptor, alpha1.861.48
IRF5NM_03264335Interferon regulatory factor 51.521.52
IL6RS72848Interleukin 6 receptor1.792.76
Cytoskeleton
FGD6NM_018351FYVE, RhoGEF, and pH domain containing 6−2.40−1.48
ABLIM3NM_014945Actin-binding LIM protein family, member 31.861.49
PFN2NM_002628Profilin 21.511.47
Ion transport
SLC24A1AF026132Solute carrier family 24 (Na/K/Ca exchanger), member 11.591.95
SLC30A1AI972416Solute carrier family 30 (zinc transporter), member 11.941.55
SLC4A4AF069510Solute carrier family 4, NaHCO3 cotransporter, member 41.521.92
EGFR signaling pathway
AKT2NM_001626v-akt murine thymoma viral oncogene homolog 22.362.19
PIK3R1NM_181523Phosphoinositide-3-kinase, regulatory subunit 1 (alpha)2.761.54
PTPN12S69182Protein tyrosine phosphatase, nonreceptor type 122.271.50