Journal of Immunology Research / 2018 / Article / Tab 6

Research Article

Immune Response to Rotavirus and Gluten Sensitivity

Table 6

Selection of genes modulated in human T84 cells after stimulation with anti-VP7 rotavirus peptide antibodies, involved in immune response and in molecular signaling related to the viral infection process.

Gene symbolGene titleFC

Immune response
CCR2Chemokine (C-C motif) receptor 2−1.48
CXCL1Chemokine (C-X-C motif) ligand 11.81
CXCL13Chemokine (C-X-C motif) ligand 13−5.52
GATA3GATA-binding protein 3−6.62
TROVE2TROVE domain family, member 2−1.64
ICOSLGInducible T cell costimulator ligand2.51
FCGR1AFc fragment of IgG, high affinity Ia, receptor (CD64)2.00
FOXP3Forkhead box P31.49
ULBP1UL16-binding protein 1−1.77
ITGA4Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)1.48
CXCL9Chemokine (C-X-C motif) ligand 91.59
CSF3Colony-stimulating factor 3 (granulocyte)1.46
IL6Interleukin 6 (interferon, beta 2)1.51
CD84CD84 molecule3.40
FCGR2BFc fragment of IgG, low affinity IIb, receptor (CD32)1.77
LAT2Linker for activation of T cells family, member 21.85
C7Complement component 73.11
CCR1Chemokine (C-C motif) receptor 13.27
CCR3Chemokine (C-C motif) receptor 32.80
CFPComplement factor properdin2.92
IL24Interleukin 242.19
IL8Interleukin 81.86
CXCL10Chemokine (C-X-C motif) ligand 101.82
IL1F7Interleukin 1 family, member 7 (zeta)−2.26
IKBKBInhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta−2.25
CCL11Chemokine (C-C motif) ligand 111.96
Type I interferon signaling
Cellular response to interferon alpha
 FCARFc fragment of IgA, receptor for2.15
Type I interferon signaling
 IFNA16Interferon, alpha 161.58
 STAT1Signal transducer and activator of transcription 1, 91 kDa−1.46
 IFNA17Interferon, alpha 171.56
 YY1YY1 transcription factor−2.24
 IFNA4Interferon, alpha 41.73
 IRF8Interferon regulatory factor 8 interferon regulatory factor 8−1.68
 IFNA5Interferon, alpha 5−2.85
 IRF2Interferon regulatory factor 21.58
 IFNA8Interferon, alpha 82.23
 IRF5Interferon regulatory factor 51.52
 IFI6Interferon, alpha-inducible protein 61.56
 IFNA6Interferon, alpha 62.08
Positive regulation of interferon alpha production
 IRF5Interferon regulatory factor 51.52
Positive regulation of interferon beta production
 DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked−1.49
 IRF5Interferon regulatory factor 51.52
Negative regulation of interferon beta production
 LILRB1Leukocyte immunoglobulin-like receptor, subfamily B, member 1−1.60
Positive regulation of Type I interferon production
 IFI16Interferon, gamma-inducible protein 16−1.68
 CREBBPCREB-binding protein (Rubinstein-Taybi syndrome)1.51
Negative regulation of Type I interferon production
 CYLDCylindromatosis (turban tumor syndrome)−3.04
Gamma interferon signaling
Cellular response to Interferon Gamma signaling
 FCARFc fragment of IgA, receptor for2.15
 MRC1Mannose receptor, C type 12.52
 SYNCRIPSynaptotagmin-binding, cytoplasmic RNA-interacting protein−1.69
 CCL8chemokine (C-C motif) ligand 81.63
Interferon gamma signaling
 STAT1Signal transducer and activator of transcription 1, 91 kDa−1.46
 MID1Midline 1 (Opitz/BBB syndrome)−1.99
 HLA-DRB4Major histocompatibility complex, class II, DR beta 42.39
 SDK1Sidekick homolog 1 (chicken)1.61
 IFNGR1Interferon gamma receptor 1 interferon gamma receptor 11.67
Negative regulation of gamma interferon production
 LILRB1Leukocyte immunoglobulin-like receptor, subfamily B, member 1−1.60
 CD244CD244 molecule, natural killer cell receptor 2B4−1.69
 IL10Interleukin 10−3.56
Positive regulation of gamma interferon production
 FOXP3Forkhead box P31.49
 IL1BInterleukin 1, beta1.80
Toll-like receptor signaling
TANKTRAF family member-associated NFKB activator−1.91
CHUKConserved helix-loop-helix ubiquitous kinase−1.72
ELK1ELK1, member of ETS oncogene family3.70
MAP3K8Mitogen-activated protein kinase kinase kinase 8−2.16
TLR6Toll-like receptor 62.43
TLR1Toll-like receptor 11.57
TLR7Toll-like receptor 7−1.64
MAP3K7Mitogen-activated protein kinase kinase kinase 7−1.89
LY96Lymphocyte antigen 96−1.81
NFKB2Nuclear factor of kappa light polypeptide gene enhancer in B cells 2 (p49/p100)1.54
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)−1.82
PTGS2Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)1.76
TNFAIP3Tumor necrosis factor, alpha-induced protein 31.73
MAP2K3Mitogen-activated protein kinase kinase 31.59
IKBKBInhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta−2.25
TLR3Toll-like receptor 3−2.03
IFNB1Interferon, beta 1, fibroblast−1.84
IRAK3Interleukin-1 receptor-associated kinase 31.70
TLR4Toll-like receptor 41.46
IKBKEInhibitor of kappa light polypeptide gene enhancer in B cells, kinase epsilon2.06
MAP2K2Mitogen-activated protein kinase kinase 21.98
TLR2Toll-like receptor 2−2.30