Immunotherapies: Exploiting the Immune System for Cancer Treatment

Figure 2

Procedure for adoptive T cell transfer with CAR T cells and TILs. Adoptive transfer of TILs and CAR T cells to target the MHC1 and CD19 antigen on a tumor cell, respectively. (a) Excision of the tumor followed by isolation and expansion of lymphocytes present from the excised tumor. Expanded cells are then infused into the patient. (b) Chimeric antigen receptor T cells are designed to target the CD19 antigen and are then infused into the patient. (c) TCR-transduced T cells are generated from patients’ PBMC and stimulated with a retrovirus containing the antigen “X”-specific TCR.