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Journal of Immunology Research
Volume 2019, Article ID 1538439, 10 pages
https://doi.org/10.1155/2019/1538439
Research Article

Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure

1Department of Infectious Diseases, The Third Affiliated Hospital of Sun-Yat-sen University, Guangzhou 510630, China
2Guangdong Provincial Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun-Yat-sen University, Guangzhou 510630, China
3Department of Ultrasound, The Third Affiliated Hospital of Sun-Yat-sen University, Guangzhou 510630, China
4Key Laboratory of Tropical Disease Control (Sun-Yat-sen University), Ministry of Education, Guangzhou 510630, China

Correspondence should be addressed to Ting Zhang; moc.361@41872413631 and Zhi-liang Gao; moc.nc12@oaggnailihz

Received 28 June 2018; Revised 11 October 2018; Accepted 21 April 2019; Published 6 May 2019

Guest Editor: Feng Li

Copyright © 2019 Geng-lin Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background and Aims. Serum immunoglobulins are frequently increased in patients with chronic liver disease, but little is known about the role of serum immunoglobulins and their correlations with interleukin-27 (IL-27) in patients with HBV-related acute-on-chronic liver failure (HBV-ACLF). This study was aimed at determining the role of serum immunoglobulin (IgG, IgA, and IgM) levels and their associations with IL-27 in noncirrhotic patients with HBV-ACLF. Methods. Samples were assessed from thirty patients with HBV-ACLF, twenty-four chronic hepatitis B (CHB) subjects, and eighteen normal controls. Disease severity of HBV-ACLF was evaluated. Serum IL-27 levels were examined by enzyme-linked immunosorbent assay. Immunoglobulin levels were assessed using immunoturbidimetric assay. Correlations between immunoglobulin levels and IL-27 were analyzed. Receiver operating characteristic (ROC) curves were used to predict the 3-month mortality. Results. 25 (83.3%) HBV-ACLF patients had elevated serum IgG levels (>1 ULN), 14 (46.7%) patients had elevated IgA, and 15 (50%) had raised IgM. IgG, IgA, and IgM levels were higher in HBV-ACLF patients than in CHB patients and normal controls. Moreover, IgG, IgA, and IgM levels were positively correlated with Tbil levels but negatively correlated with prothrombin time activity (PTA) levels. Additionally, IgG levels were significantly increased in nonsurviving patients than in surviving HBV-ACLF patients () and positively correlated with MELD score (, ). Also, IgG levels were positively correlated with IL-27 levels in HBV-ACLF patients (, ). Furthermore, ROC curve showed that IgG levels could predict the 3-month mortality in HBV-ACLF patients (the area under the ROC curve: 0.752, ). Conclusions. Our findings demonstrated that serum immunoglobulins were preferentially elevated in HBV-ACLF patients. IgG levels were positively correlated with IL-27 and may predict prognosis in HBV-ACLF patients.