Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure

Figure 3

IgG levels were closely associated with disease severity in HBV-ACLF patients. (a) IgG levels were significantly lower in HBV-ACLF patients at the descent stage than patients at the ascent stage () and patients at the plateau stage (). However, no significant differences existed in IgA or IgM levels among HBV-ACLF patients at different stages. (b) Serum IgG levels were significantly higher in nonsurviving HBV-ACLF patients than in surviving patients (). Also, we noticed that serum IgM levels were slightly higher in nonsurviving HBV-ACLF patients than in surviving patients (). (c) Positive correlations were found between IgG levels and MELD score, between IgA levels and CLIF-C ACLF score. And a positive correlation trend was found between IgG levels and MELD-Na score. ; ; ns: not significant; solid line: linear growth trend; : correlation coefficient.

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(b)

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