Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure

Table 1

Clinical characteristics of the participants enrolled in the study.

Groups	NC ()	CHB ()	HBV-ACLF ()
Gender (male)	17	24	29
Age (years)
ALT (U/L)		186.5 (34-2424)	187.5 (27-2879)
AST (U/L)		211.5 (56-2646)	163 (66-1859)
Tbil (μmol/L)	N.D.	186.9 (39.1-826.2)	489.6 (204.5-1157.0)
PTA (%)	N.D.	85 (46-126)	34 (14-40)
Albumin (g/L)	N.D.	40.2 (35.4-50.7)
Globulin (g/L)	N.D.	29.9 (22.8-43.9)
HBV-DNA (log10IU/mL)	N.D.
Complication	0	0	22
SBP	0	0	19
Hepatic encephalopathy	0	0	11
Hepatorenal syndrome	0	0	2
UGB	0	0	1
MELD score	N.D.	N.D.
MELD-Na score	N.D.	N.D.
CLIF-C ACLF score	N.D.	N.D.
IgG (g/L)		16.83 (8.86-30.76)
Elevated IgG (>1 ULN)	0	13	25
IgA (g/L)
Elevated IgA (>1 ULN)	0	6	14
IgM (g/L)	0.92 (0.54-1.75)	1.38 (0.75-3.47)	2.19 (1.09-5.41)
Elevated IgM (>1 ULN)	0	2	15
HBsAg positive	0	24	30
HBsAb positive	18	0	0
HbeAg positive	0	16	12

Data are shown as or medians and ranges. ACLF: acute-on-chronic liver failure; CHB: chronic hepatitis B; NC: normal control; ALT: alanine aminotransferase; AST: aspartate aminotransferase; Tbil: total bilirubin; PTA: prothrombin time activity; SBP: spontaneous bacterial peritonitis; UGB: upper gastrointestinal bleeding; MELD: model for end-stage liver disease; CLIF-C: Chronic Liver Failure Consortium; IgG: immunoglobulin G; IgA: immunoglobulin A; IgM: immunoglobulin M; ULN: upper limit of normal; N.D: not determined.