Research Article

The Functions and Mechanism of a New Oligopeptide BP9 from Avian Bursa on Antibody Responses, Immature B Cell, and Autophagy

Figure 2

BP9 induced the strong antibody response in JEV vaccine immunization models. Mice were immunized with JEV vaccine and BP9 following prime-boost vaccinations strategy. Total IgG (a), IgG2a (b), and IgG1 (c) were shown. Serum samples from all immunized mice were collected at two, four, and six weeks after the first immunization to detect the IgG and subtype antibody levels by the ELISA method, respectively. (c) Neutralization antibodies. The neutralization antibodies in mice immunized with BP9 and JEV vaccine were measured by plaque formation. Data represent . and , compared with that of the peptide control.
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