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Journal of Immunology Research
Volume 2019, Article ID 2015892, 8 pages
https://doi.org/10.1155/2019/2015892
Research Article

Local Administration of Caloric Restriction Mimetics to Promote the Immune Control of Lung Metastases

1Molecular Targeting Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy
2Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan 20133, Italy

Correspondence should be addressed to Lucia Sfondrini; ti.iminu@inirdnofs.aicul

Received 30 November 2018; Revised 1 April 2019; Accepted 4 June 2019; Published 20 June 2019

Academic Editor: Patrice Petit

Copyright © 2019 Valentino Le Noci et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. H. O’Flanagan, L. A. Smith, S. B. McDonell, and S. D. Hursting, “When less may be more: calorie restriction and response to cancer therapy,” BMC Medicine, vol. 15, no. 1, p. 106, 2017. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Marino, F. Pietrocola, F. Madeo, and G. Kroemer, “Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers,” Autophagy, vol. 10, no. 11, pp. 1879–1882, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Madeo, F. Pietrocola, T. Eisenberg, and G. Kroemer, “Caloric restriction mimetics: towards a molecular definition,” Nature Reviews Drug Discovery, vol. 13, no. 10, pp. 727–740, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Chen, H. Zhuang, X. Chen, Z. Shi, and X. Wang, “Spermidine induced growth inhibition and apoptosis via autophagic activation in cervical cancer,” Oncology Reports, vol. 39, no. 6, pp. 2845–2854, 2018. View at Publisher · View at Google Scholar · View at Scopus
  5. F. Yue, W. Li, J. Zou et al., “Spermidine prolongs lifespan and prevents liver fibrosis and hepatocellular carcinoma by activating MAP1S-mediated autophagy,” Cancer Research, vol. 77, no. 11, pp. 2938–2951, 2017. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Schwartz, A. Guais, M. Israel et al., “Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin,” Investigational New Drugs, vol. 31, no. 2, pp. 256–264, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. F. Pietrocola, J. Pol, E. Vacchelli et al., “Caloric restriction mimetics enhance anticancer immunosurveillance,” Cancer Cell, vol. 30, no. 1, pp. 147–160, 2016. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Rao, L. Tortola, T. Perlot et al., “A dual role for autophagy in a murine model of lung cancer,” Nature Communications, vol. 5, no. 1, article 3056, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. F. Bianchi, M. Sasso, F. Turdo et al., “Fhit nuclear import following EGF stimulation sustains proliferation of Breast Cancer cells,” Journal of Cellular Physiology, vol. 230, no. 11, pp. 2661–2670, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. L. Galluzzi, J. M. Bravo-San Pedro, B. Levine, D. R. Green, and G. Kroemer, “Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles,” Nature Reviews Drug Discovery, vol. 16, no. 7, pp. 487–511, 2017. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Hussell and T. J. Bell, “Alveolar macrophages: plasticity in a tissue-specific context,” Nature Reviews Immunology, vol. 14, no. 2, pp. 81–93, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Storti, V. Le Noci, M. Sommariva, E. Tagliabue, A. Balsari, and L. Sfondrini, “Aerosol delivery in the treatment of lung cancer,” Current Cancer Drug Targets, vol. 15, no. 7, pp. 604–612, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. V. Le Noci, M. Sommariva, M. Tortoreto et al., “Reprogramming the lung microenvironment by inhaled immunotherapy fosters immune destruction of tumor,” OncoImmunology, vol. 5, no. 11, article e1234571, 2016. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Nanni, S. M. Pupa, G. Nicoletti et al., “p185neu protein is required for tumor and anchorage-independent growth, not for cell proliferation of transgenic mammary carcinoma,” International Journal of Cancer, vol. 87, no. 2, pp. 186–194, 2000. View at Publisher · View at Google Scholar
  15. P. Workman, E. O. Aboagye, F. Balkwill et al., “Guidelines for the welfare and use of animals in cancer research,” British Journal of Cancer, vol. 102, no. 11, pp. 1555–1577, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. V. Le Noci, M. Tortoreto, A. Gulino et al., “Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment,” OncoImmunology, vol. 4, no. 10, article e1040214, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Lo Russo, M. Moro, M. Sommariva et al., “Antibody-Fc/FcR interaction on macrophages as a mechanism for hyperprogressive disease in non-small cell lung cancer subsequent to PD-1/PD-L1 blockade,” Clinical Cancer Research, vol. 25, no. 3, pp. 989–999, 2019. View at Publisher · View at Google Scholar · View at Scopus
  18. F. Bianchi, M. Sommariva, L. De Cecco et al., “Expression and prognostic significance of the autoimmune regulator gene in breast cancer cells,” Cell Cycle, vol. 15, no. 23, pp. 3220–3229, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Sommariva, V. Le Noci, C. Storti et al., “Activation of NK cell cytotoxicity by aerosolized CpG-ODN/poly(I:C) against lung melanoma metastases is mediated by alveolar macrophages,” Cellular Immunology, vol. 313, pp. 52–58, 2017. View at Publisher · View at Google Scholar · View at Scopus
  20. A. De Cesare, L. Sfondrini, M. Pennati et al., “CpG-oligodeoxynucleotides exert remarkable antitumor activity against diffuse malignant peritoneal mesothelioma orthotopic xenografts,” Journal of Translational Medicine, vol. 14, no. 1, p. 25, 2016. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Turdo, F. Bianchi, P. Gasparini et al., “CDCP1 is a novel marker of the most aggressive human triple-negative breast cancers,” Oncotarget, vol. 7, no. 43, pp. 69649–69665, 2016. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Di Modica, L. Sfondrini, V. Regondi et al., “Taxanes enhance trastuzumab-mediated ADCC on tumor cells through NKG2D-mediated NK cell recognition,” Oncotarget, vol. 7, no. 1, pp. 255–265, 2016. View at Publisher · View at Google Scholar · View at Scopus
  23. O. Meynet and J. E. Ricci, “Caloric restriction and cancer: molecular mechanisms and clinical implications,” Trends in Molecular Medicine, vol. 20, no. 8, pp. 419–427, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. G. S. Kopeina, V. V. Senichkin, and B. Zhivotovsky, “Caloric restriction - a promising anti-cancer approach: from molecular mechanisms to clinical trials,” Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol. 1867, no. 1, pp. 29–41, 2017. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Sfondrini, M. Sommariva, M. Tortoreto et al., “Anti-tumor activity of CpG-ODN aerosol in mouse lung metastases,” International Journal of Cancer, vol. 133, no. 2, pp. 383–393, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. A. M. Gil-Bernabe, S. Ferjancic, M. Tlalka et al., “Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice,” Blood, vol. 119, no. 13, pp. 3164–3175, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. N. Mizushima, T. Yoshimori, and B. Levine, “Methods in mammalian autophagy research,” Cell, vol. 140, no. 3, pp. 313–326, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. G. Kroemer and L. Galluzzi, “Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors,” Oncotarget, vol. 8, no. 4, pp. 5686–5691, 2017. View at Publisher · View at Google Scholar · View at Scopus
  29. S.-S. J. Sung, S. M. Fu, C. E. Rose, F. Gaskin, S. T. Ju, and S. R. Beaty, “A major lung CD103 (αE)-β7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins,” The Journal of Immunology, vol. 176, no. 4, pp. 2161–2172, 2006. View at Publisher · View at Google Scholar
  30. T. Fan, L. Chen, Z. Huang et al., “Autophagy decreases alveolar macrophage apoptosis by attenuating endoplasmic reticulum stress and oxidative stress,” Oncotarget, vol. 7, no. 52, pp. 87206–87218, 2016. View at Publisher · View at Google Scholar · View at Scopus
  31. F. Pietrocola, J. Pol, E. Vacchelli et al., “Autophagy induction for the treatment of cancer,” Autophagy, vol. 12, no. 10, pp. 1962–1964, 2016. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Sun, H. Wang, Z. He et al., “Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages,” Oncotarget, vol. 8, no. 43, pp. 74649–74660, 2017. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Lopez-Soto, J. M. Bravo-San Pedro, G. Kroemer, L. Galluzzi, and S. Gonzalez, “Involvement of autophagy in NK cell development and function,” Autophagy, vol. 13, no. 3, pp. 633–636, 2017. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Iannello, T. W. Thompson, M. Ardolino, S. W. Lowe, and D. H. Raulet, “p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells,” Journal of Experimental Medicine, vol. 210, no. 10, pp. 2057–2069, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Park, H. Shin, H. Song, and H. J. Lim, “Autophagic regulation in steroid hormone-responsive systems,” Steroids, vol. 115, pp. 177–181, 2016. View at Publisher · View at Google Scholar · View at Scopus
  36. J. Xiang, X. Liu, J. Ren et al., “How does estrogen work on autophagy?” Autophagy, vol. 15, no. 2, pp. 197–211, 2019. View at Publisher · View at Google Scholar · View at Scopus