Impact of SNPs/Haplotypes of IL10 and IFNG on the Development of Diffuse Large B-Cell Lymphoma
Table 2
Distribution of the genotype frequencies in cytokine genes and the haplotype frequencies of IL10 and TGFB1 in patients with DLBCL and controls.
Genotypes
Frequency
OR (95% CI)
Patients
(%)
Controls
(%)
Polymorphisms
TNF -308G>A rs1800629
G/G
85 (75.9)
160 (72.4)
G/A
26 (23.2)
54 (24.4)
NS
A/A
1 (0.9)
7 (3.2)
TGFB1 codon10T>C rs1982073
T/T
28 (25.0)
66 (29.9)
T/C
61 (54.5)
106 (48.0)
NS
C/C
23 (20.5)
49 (22.2)
TGFB1 codon25G>C rs1800471
G/G
96 (85.7)
196 (88.7)
G/C
15 (13.4)
22 (9.9)
NS
C/C
1 (0.9)
3 (1.4)
IL10 -1082A>G rs1800896
A/A
49 (43.8)
87 (39.4)
G/A
55 (49.1)
104 (47.1)
NS
G/G
8 (7.1)
30 (13.6)
IL10 -819C>T rs1800871
C/C
36 (32.1)
101 (45.7)
1
C/T
58 (51.8)
90 (40.7)
2.23 (1.16-4.29)
0.013
T/T
18 (16.1)
30 (13.6)
IL10 -592C>A rs1800872
C/C
6 (32.1)
101 (45.7)
1
C/A
58 (51.8)
90 (40.7)
2.23 (1.16-4.29)
0.013
A/A
18 (16.1)
30 (13.6)
IL6 -174G>C rs1800795
G/G
59 (52.7)
95 (43.0)
G/C
41 (36.6)
99 (44.8)
NS
C/C
12 (10.7)
27 (12.2)
IFNG +874A>T rs2430561
A/A
57 (50.9)
61 (27.6)
1
A/T
38 (33.9)
117 (52.9)
0.35 (0.19-0.65)
<0.01
T/T
17 (15.2)
43 (19.5)
Haplotypes
IL10 -1082, -819, and -592
ATA
0.419
0.339
1
GCC
0.317
0.371
NS
ACC
0.263
0.289
0.55 (0.32-0.95)
0.03
TGFB1 codon10, codon25
TG
0.516
0.529
1
CG
0.409
0.407
NS
CC
0.069
0.055
NS
TC
0.006
0.009
NS
NS: not significant; : population size; : number of individuals with the allele or genotype; %: genotype and ;: value (adjusted by age and gender); OR: odds ratio; CI: confidence interval. Best model: dominant—a single copy of the mutant allele is sufficient to modify the risk. The best inheritance model was chosen according to the lowest Akaike information criterion (AIC).