Research Article

Impact of SNPs/Haplotypes of IL10 and IFNG on the Development of Diffuse Large B-Cell Lymphoma

Table 2

Distribution of the genotype frequencies in cytokine genes and the haplotype frequencies of IL10 and TGFB1 in patients with DLBCL and controls.

GenotypesFrequencyOR (95% CI)
Patients

(%)
Controls

(%)

Polymorphisms
TNF -308G>A
rs1800629
G/G85 (75.9)160 (72.4)
G/A26 (23.2)54 (24.4)NS
A/A1 (0.9)7 (3.2)
TGFB1 codon10T>C
rs1982073
T/T28 (25.0)66 (29.9)
T/C61 (54.5)106 (48.0)NS
C/C23 (20.5)49 (22.2)
TGFB1 codon25G>C rs1800471G/G96 (85.7)196 (88.7)
G/C15 (13.4)22 (9.9)NS
C/C1 (0.9)3 (1.4)
IL10 -1082A>G
rs1800896
A/A49 (43.8)87 (39.4)
G/A55 (49.1)104 (47.1)NS
G/G8 (7.1)30 (13.6)
IL10 -819C>T
rs1800871
C/C36 (32.1)101 (45.7)1
C/T58 (51.8)90 (40.7)2.23 (1.16-4.29)0.013
T/T18 (16.1)30 (13.6)
IL10 -592C>A
rs1800872
C/C6 (32.1)101 (45.7)1
C/A58 (51.8)90 (40.7)2.23 (1.16-4.29)0.013
A/A18 (16.1)30 (13.6)
IL6 -174G>C
rs1800795
G/G59 (52.7)95 (43.0)
G/C41 (36.6)99 (44.8)NS
C/C12 (10.7)27 (12.2)
IFNG +874A>T
rs2430561
A/A57 (50.9)61 (27.6)1
A/T38 (33.9)117 (52.9)0.35 (0.19-0.65)<0.01
T/T17 (15.2)43 (19.5)

Haplotypes
IL10 -1082, -819, and -592ATA0.4190.3391
GCC0.3170.371NS
ACC0.2630.2890.55 (0.32-0.95)0.03
TGFB1
codon10, codon25
TG0.5160.5291
CG0.4090.407NS
CC0.0690.055NS
TC0.0060.009NS

NS: not significant; : population size; : number of individuals with the allele or genotype; %: genotype and ; : value (adjusted by age and gender); OR: odds ratio; CI: confidence interval. Best model: dominant—a single copy of the mutant allele is sufficient to modify the risk. The best inheritance model was chosen according to the lowest Akaike information criterion (AIC).