Impact of SNPs/Haplotypes of IL10 and IFNG on the Development of Diffuse Large B-Cell Lymphoma
Table 3
Distribution of genotype frequencies in cytokine genes and in the haplotype frequencies of IL10 and TGFB1 in patients treated with R-CHOP and considering the prognosis of the disease.
Genotypes
Frequency
OR (95% CI)
Death, relapse, or progression
Complete remission
(%)
(%)
Polymorphisms
TNF -308G>A rs1800629
G/G
23 (92.0)
52 (72.2)
G/A
2 (8.0)
20 (27.8)
NS
A/A
TGFB1 codon10T>C rs1982073
T/T-C/C
4 (16.0)
20 (27.8)
1.00
T/C
17 (68.0)
35 (48.6)
2.89 (1.04-8.05)
0.03
TGFB1 codon25G>C rs1800471
G/G
19 (76.0)
64 (88.9)
G/C
5 (20.0)
8 (11.1)
NS
C/C
1 (4.0)
0 (0)
IL10 -1082A>G rs1800896
A/A
13 (52.0)
28 (38.9)
G/A
12 (48.0)
37 (51.4)
NS
G/G
0 (0)
7 (9.7)
IL10 -819C>T rs1800871
C/C
9 (36.0)
23 (31.9)
C/T
14 (56.0)
37 (51.4)
NS
T/T
2 (8.0)
12 (16.7)
IL10 -592C>A rs1800872
C/C
9 (36.0)
23 (31.9)
C/A
14 (56.0)
37 (51.4)
NS
A/A
2 (8.0)
12 (16.7)
IL6 -174G>C rs1800795
G/G
12 (48.0)
40 (55.6)
G/C
11 (44.0)
23 (31.9)
NS
C/C
2 (8.0)
9 (12.5)
IFNG +874A>T rs2430561
A/A
11 (44.0)
36 (50.0)
A/T
9 (36.0)
26 (36.1)
NS
T/T
5 (20.0)
10 (13.9)
Haplotypes
IL10 -1082, -819, and -592
ATA
0.360
0.424
1
GCC
0.240
0.354
NS
ACC
0.400
0.222
2.83 (1.11-7.18)
0.03
TGFB1 codon10, codon25
TG
0.510
0.500
1
CG
0.434
0.360
NS
CC
0.045
0.140
NS
TC
0.001
0
NS
NS: not significant; : population size; : number of individuals with the allele or genotype; %: genotype and ;: value (adjusted by age and gender); OR: odds ratio; CI: confidence interval. Best model: overdominant—heterozygous alleles are compared to a pool of both homozygous alleles. The best inheritance model was chosen according to the lowest Akaike information criterion (AIC).
