Journal of Immunology Research

Review Article

Immunopathology of Airway Surface Liquid Dehydration Disease

Table 2

Various genetic modifications in the Scnn1b-Tg+ mouse model.


Genotype	Description	Macrophage infiltration	Neutrophil infiltration	Eosinophil infiltration	Lymphocyte infiltration	Mucous cell metaplasia	Airway mucus obstruction	Distal airspace enlargement	Reference

Tnfα^-/--Scnn1b-Tg+	Global deletion of Tnfα	No significant difference	No significant difference	No significant difference	No significant difference	No significant difference	No significant difference	No significant difference	(Livraghi et al., [65])
Tnfr1^-/--Scnn1b-Tg+	Global deletion of Tnfr1	No significant difference	No significant difference	No significant difference	No significant difference	No significant difference	No significant difference	No significant difference	(Livraghi et al., [65])
Il4rα^-/--Scnn1b-Tg+	Global deletion of Il4rα	No significant difference	No significant difference	Significantly reduced at PND 10 and 5 weeks of age	No significant difference	Significantly reduced at PND 10	No significant difference	No significant difference	(Livraghi et al., [65])
Myd88^-/-Scnn1b-Tg+	Global deletion of Myd88	Significantly higher at PND 10; no significant difference at other observed time-points	Significantly reduced	No significant difference	Lymphoid hyperplasia significantly increased at 8 weeks of age	Significantly reduced at PND 5-7, but not at other time-points	Significantly reduced at PND 5-7, but not at any other observed time-point	Not reported	(Livraghi-Butrico et al., [38])
Ne^-/--Scnn1b-Tg+	Global deletion of neutrophil elastase	No significant difference	Significantly reduced	No significant difference	No significant difference	Significantly reduced	No significant difference	Significantly reduced	(Gehrig et al., [57])
Il1r^-/--Scnn1b-Tg+	Global deletion of Il1r	No significant difference	Significantly reduced	No significant difference	No significant difference	Not reported	Significantly reduced	Significantly reduced	(Fritzsching et al., [97])
DTA⁺-Scnn1b-Tg+	Partial deficiency of macrophages	No significant difference in total number of macrophage infiltration, significantly reduced in total percentage	Significantly increased	No significant difference	Increased occurrence of lymphoid aggregates in adult mice; significant infiltration in nonemaciated phenotype	Significantly reduced in emaciated phenotype	Significantly reduced in emaciated phenotype	No significant difference	(Saini et al., [51, 53])
Muc5b^-/--Scnn1b-Tg+	Global deletion of Muc45b	No significant difference	No significant difference	Not reported	Increased lymphoid aggregates, but no significant difference in BALF lymphocytes	Not reported	Significantly reduced	No significant difference	(Livraghi-Butrico et al., [108])
Muc5ac^-/--Scnn1b-Tg+	Global deletion of Muc5ac	No significant difference	No significant difference	Not reported	No significant difference in incidence of lymphoid aggregates	Not reported	Significantly reduced	Not reported	(Livraghi-Butrico et al., [108])
Spdef^-/--Scnn1b-Tg+	Global deletion of Spdef	No significant difference	Significantly increased in neonates	No significant difference	No significant difference	Not reported	No significant difference	Not reported	(Chen et al., [109])