Innate Lymphoid Cells: Regulators of Gut Barrier Function and Immune Homeostasis

Table 1

List of some important studies in ILC research history.

Years	Events	Reference #
1975	Discovery of NK cells as the first subsets of ILCs	[63]
1997	Discovery of LTi cells (later defined as one subset of ILC3s) which are essential for the development of lymph nodes during embryogenesis	[64]
2006	Characterization of GATA3 and CD127 on ILC2s	[65]
2009	ILC3s are the source of endogenous IL-22 and constrain inflammation at the mucosal site	[66]
2010	Identification of ILC2s in mice that produce type 2 cytokines and contribute to antihelminth immunity and type 2 inflammation	[67]
2010	Identification of a role for ILC3-like cells in promoting intestinal inflammation	[68]
2011	First description of a tissue-protective role for ILC2s, describing how ILC2s produce amphiregulin, a ligand of EGFR, and contribute to lung-tissue repair following influenza A virus infection in mice	[69]
2013	First evidence of non-NK cell ILC1s in humans and the transcription factor T-bet responsible for ILC1s differentiation	[70, 71]
2013	First evidence that ILC3s directly regulate adaptive immune responses	[72]
2013	Experts described consensus nomenclature for ILC subsets	[73]