A Novel Anti-EGFR mAb Ame55 with Lower Toxicity and Better Efficacy than Cetuximab When Combined with Irinotecan

Figure 3

Antitumor effect of Ame55 alone or combined with irinotecan (CPT-11) in A431 and Lovo cell xenografts. Mice were injected and treated as indicated in Materials and Methods with (a) cetuximab (0.25, 0.5 nM); (b) Ame55 (0.25, 0.5, and 1 nM); (c) IHC analysis of PCNA expression for tumor cell proliferation inhibition in xenograft tumors (0.5 nM); (d-f) A431 cell xenograft mice () were treated as described in Materials and Methods; (e-g) Lovo cell xenograft mice were treated as described in Materials and Methods.

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