PM2.5 Exposure in the Respiratory System Induces Distinct Inflammatory Signaling in the Lung and the Liver of Mice

Figure 4

Comparison of mRNA expression pattern in the lung and the liver after PM2.5 treatment. (a, b) Microarray cluster images comparing the PM2.5 treatment groups and control group of the lung and the liver, respectively. (c, d) The 20 most significant Kyoto Encyclopedia Gene and Genome (KEGG) pathways with increased mRNA expression after PM2.5 treatment were shown for each organ. The red box showed the pathways associated with the immune system, cytokines, and human disease. (e, f) The GSEA results of the IFN-γ response pathway were shown; the common pathway in the lung and the liver of mice assessed 48 h post-PM2.5 treatment was significantly increased with an NES of 1.792 and 1.434, respectively. (g) Quantitative real-time PCR analysis ( method) of CCL5 gene expression was shown in the control group and the 48 h post-PM2.5 treatment group of the lung and the liver. Data was presented as ().

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