Cross-Disease Innate Gene Signature: Emerging Diversity and Abundance in RA Comparing to SLE and SSc

Table 2

Relative mRNA expression levels of genes differentially expressed between (a) RA vs. SLE, (b) RA vs. SSc, (c) SSc vs. SLE.

(a) RA vs. SLE

Gene	Mean (95% CI)		FC	value
	RA	SLE
TLR5	0.056 (0.043-0.070)	0.021 (0.011-0.032)	6.49
SIGIRR	0.300 (0.247-0.353)	0.179 (0.141-0.218)	1.76
TLR2	0.077 (0.059-0.095)	0.046 (0.029-0.063)	2.00

(b) RA vs. SSc

Gene	Mean (95% CI)		FC	value
	RA	SSc
IL1RAP	0.015 (0.011-0.020)	0.003 (0.001-0.004)	6.08
TLR5	0.056 (0.043-0.070)	0.013 (0.007-0.019)	7.16
IL18R1	0.011 (0.008-0.014)	0.003 (0.002-0.005)	4.08
SIGIRR	0.300 (0.247-0.353)	0.155 (0.098-0.211)	2.26
TLR3	0.005 (0.003-0.007)	0.001 ()	28.5

(c) SSc vs. SLE

Gene	Mean (95% CI)		FC	value
	SSc	SLE
IL1R1	0.004 (0.003-0.005)	0.002 ()	34.8

value corrected for multiple comparisons (Benjamini-Hochberg correction). FC (fold change) between group medians of relative mRNA expression levels.