Myeloperoxidase and Eosinophil Peroxidase Inhibit Endotoxin Activity and Increase Mouse Survival in a Lipopolysaccharide Lethal Dose 90% Model

Table 1

Tabulated inhibition statistics for in vitro LAL assay studies.

Figures	Dependent variable,	Independent variable,			Coefficient of determination, R^2	Adjusted R^2	Std. error of the regression,	statistic change	Degrees of freedom		Sig. change
			β0	β1					df1	df2	value
1(b)	% inhibition (5 ng LPS)	MPO (mg)	93.6	13.4	0.9348	0.9337	6.34	831.7	1	58
2	% inhibition (0.1 ng LPS)	MPO (mg)	127.0	33.3	0.8945	0.8897	14.15	186.5	1	22
2	% inhibition (0.1 ng LPS)	EPO (mg)	115.0	46.7	0.8894	0.8815	13.65	112.6	1	14
2	% inhibition (0.1 ng LPS)	GO (mg)	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
3(b)	% of inhibition (2.16 μg lipid A)	MPO (mg)	109.3	39.4	0.9233	0.9204	9.55	313.1	1	26
3(b)	% of inhibition (2.16 μg lipid A)	EPO (mg)	77.0	48.9	0.9268	0.9228	8.29	228.0	1	18
4	% inhibition (4 μg MPO: 0.8 μg GO)	LPS (ng)	7.1	-19.1	0.9005	0.8756	9.03	36.2	1	4	0.0038
	Without glucose (inactive)
4	% inhibition (4 μg MPO: 0.8 μg GO)	LPS (ng)	10.8	-15.0	0.8747	0.8434	8.04	27.9	1	4	0.0061
	With glucose (active)

ANOVA and regression analyses were performed with IBM SPSS Statistics Software version 17.0.