MTOR-Mediated Autophagy Is Involved in the Protective Effect of Ketamine on Allergic Airway Inflammation
Effect of ketamine on autophagy in the lungs from mice sensitized to OVA. (a, b) Electron micrographs and quantification of autophagic vacuoles. (c–j) With Western blot, MTOR, p-MTOR, LC-3I, LC-3II, and Beclin-1 were determined and quantified. (k, l) With immunohistochemistry (magnification, ×200), p-MTOR were determined and quantified. Data are expressed as the mean ± SD of six mice per group. ,, and versus the control group; and versus the OVA group.