A Single 48 mg Sucralose Sip Unbalances Monocyte Subpopulations and Stimulates Insulin Secretion in Healthy Young Adults

Figure 1

Blood levels of glucose and insulin in healthy young adults that received sucralose or placebo during an oral glucose tolerance test. Volunteers randomly received 60 mL water as placebo () or 48 mg sucralose dissolved in 60 mL water () 15 min prior to a 75 g oral glucose tolerance test (OGTT). Starting with glucose load at minute zero, venous blood samples were drawn from all study subjects every 15 min for 180 min for quantifying the blood levels of glucose and insulin. (a) Blood glucose did not show significant changes in subjects receiving placebo or sucralose all along the OGTT. (b) Serum insulin significantly increased at 30, 45, and 180 min in volunteers that received sucralose as compared to placebo controls. Timing of stimulation with sucralose, placebo, or glucose is shown on the graphic by black arrows. The placebo group is shown in open circles, whereas the sucralose group can be seen in closed circles. Data are expressed as error. Significant differences between subjects receiving placebo or sucralose were estimated on each point of the OGTT by performing two-tailed 2-way ANOVA with correction for multiple comparisons by means of the Bonferroni multiple comparisons test. Significant differences are indicated by asterisks. Differences were considered significant when .

(a)

(b)