The Role of TLR4 Asp299Gly and TLR4 Thr399Ile Polymorphisms in the Pathogenesis of Urinary Tract Infections: First Evaluation in Infants and Children of Greek Origin

Table 6

Analysis of the relation between genotypes and the number of urinary tract infections and findings of the ultrasound.

	Number of episodes
SNPs	Genotypes	Group Α ()		Group Α1 ()		Group Α2 ()
		1	≥2	1	≥2	1	≥2
TLR4 Asp299Gly	AA	29 (70.7)	7 (70)	19 (73)	6 (66.7)	11 (73.3)	2 (100)
		12 (29.3)	3 (30)	7 (27)	3 (33.3)	4 (26.7)	0 (0)
		0.9637		0.713		0.4036
TLR4 Thr399Ile	CC	40 (97.6)	10 (100)	25 (96.2)	9 (100)	15 (100)	1 (100)
		1 (2.4)	0 (0)	1 (3.8)	0 (0)	0 (0)	0 (0)
		0.6179		0.5505		NA
	Findings of the ultrasound
SNPs	Genotypes	Group Α ()		Group Α1 ()		Group Α2 ()
		Normal (%)	Pathological (%)	Normal (%)	Pathological (%)	Normal (%)	Pathological (%)
TLR4 Asp299Gly	AA	27 (71)	10 (77)	19 (73)	6 (66.7)	8 (66.7)	4 (100)
		11 (29)	3 (23)	7 (27)	3 (33.3)	4 (33.3)	0 (0)
		0.4961		0.7137		0.1824
TLR4 Thr399Ile	CC	37 (97.3)	13 (100)	25 (96.1)	8 (100)	12 (100)	4 (100)
	CT+TT	1 (2.7)	0 (0)	1 (3.9)	0 (0)	0 (0)	0 (0)
		0.5547		0.5734		NA