Journal of Immunology Research / 2019 / Article / Tab 6

Research Article

The Role of TLR4 Asp299Gly and TLR4 Thr399Ile Polymorphisms in the Pathogenesis of Urinary Tract Infections: First Evaluation in Infants and Children of Greek Origin

Table 6

Analysis of the relation between genotypes and the number of urinary tract infections and findings of the ultrasound.

Number of episodes
SNPsGenotypesGroup Α ()Group Α1 ()Group Α2 ()
1≥21≥21≥2

TLR4 Asp299GlyAA29 (70.7)7 (70)19 (73)6 (66.7)11 (73.3)2 (100)
12 (29.3)3 (30)7 (27)3 (33.3)4 (26.7)0 (0)
0.96370.7130.4036
TLR4 Thr399IleCC40 (97.6)10 (100)25 (96.2)9 (100)15 (100)1 (100)
1 (2.4)0 (0)1 (3.8)0 (0)0 (0)0 (0)
0.61790.5505NA

Findings of the ultrasound
SNPsGenotypesGroup Α ()Group Α1 ()Group Α2 ()
Normal (%)Pathological (%)Normal (%)Pathological (%)Normal (%)Pathological (%)

TLR4 Asp299GlyAA27 (71)10 (77)19 (73)6 (66.7)8 (66.7)4 (100)
11 (29)3 (23)7 (27)3 (33.3)4 (33.3)0 (0)
0.49610.71370.1824
TLR4 Thr399IleCC37 (97.3)13 (100)25 (96.1)8 (100)12 (100)4 (100)
CT+TT1 (2.7)0 (0)1 (3.9)0 (0)0 (0)0 (0)
0.55470.5734NA

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