Research Article

KIR/HLA Gene Profile Implication in Systemic Sclerosis Patients from Mexico

Table 2

KIR and HLA gene frequencies in SSc patients and CS.

SSc ()CS ()OR95% CI
CF% CFGF CF% CFGF

KIR2DL147940.768796.70.82
KIR2DL232640.403033.30.180.00073.61.7-7.30.011
KIR2DL346920.728796.70.82
KIR3DL144880.6581900.68
KIR3DL2501001.008897.80.85
KIR2DS123460.274246.70.27
KIR2DS218360.202831.10.17
KIR2DS38160.081415.60.08
KIR2DS441820.588088.90.67
2DS4full/del12240.132527.80.15
2DS4full18360.205156.70.340.020.40.2-0.90.09
2DS4del12240.1344.40.020.0016.82.1-22.40.021
2DS4neg8160.081011.10.06
KIR2DS520400.233741.10.23
KIR3DS124480.283943.30.25
KIR2DP146920.728796.70.82
KIR3DL3501001.00901001.00
KIR2DL4501001.00901001.00
KIR2DL526520.3146510.30
KIR3DP149980.86901001.00
HLA-C141820.5882910.70
HLA-C237740.4948530.310.022.51.2-5.30.09
HLA-ABw448960.8075830.59
HLA-Bw4Iso8011220.1223260.14
HLA-Bw4Thr805100.05780.04
HLA-A03480.041011.10.06
HLA-A11360.0311.10.005

CF: Carrier Frequencies; GF: Gene Frequencies; KIR: Killer-cell Immunoglobulin-like Receptors; HLA: Human Leukocyte Antigen; SSc: Systemic Sclerosis; CS: Control Subjects; CI: Confidence Interval. KIR2DS4full/del includes individuals with a copy of the full gene and del variant; 2DS4full includes individuals with one or two copies of the full gene; 2DS4del includes individuals with one or two copies of the del variant; and 2DS4neg includes individuals without KIR2DS4. based on Fisher’s exact test and adjusted based on Holm-Bonferroni correction for multiple comparisons.