KIR/HLA Gene Profile Implication in Systemic Sclerosis Patients from Mexico
Table 3
Combinations between the KIR gene and the HLA-I ligand.
KIR/HLA
SSc (%) ()
CS (%) ()
OR
95% CI
KIR2DL2+/HLA-C1+
54 (27)
32.2 (29)
0.02
2.5
1.2–5.0
0.08
KIR2DL2+/HLA-C2+
44 (44)
22.2 (20)
0.01
2.8
1.3–5.8
0.045
KIR2DS4full+/HLA-C1+
50 (25)
75.6 (68)
0.003
0.3
0.2–0.7
0.01
KIR2DL2-/HLA-C1+
28 (14)
58.9 (53)
0.001
0.3
0.1–0.6
0.004
KIR2DL2-/HLA-C2-
6 (3)
35.6 (32)
< 0.0001
0.1
0.03–0.4
0.0004
KIR2DS4del-/HLA-C2-
6 (3)
31.1 (28)
0.0005
0.1
0.04–0.5
0.002
KIR: Killer-cell Immunoglobulin-like Receptors; HLA: Human Leukocyte Antigen; SSc: Systemic Sclerosis; CS: Control Subjects. based on Fisher’s exact test and adjusted based on Holm-Bonferroni correction for multiple comparisons.
