Parametric parameters were presented as . Differences between healthy controls and COPD patients († and ). values were based on unpaired -tests. was considered significant. COPD: chronic obstructive pulmonary disease; ICS: inhaled corticosteroid; LABA: inhaled long-acting beta adrenergic antagonist; LAMA: inhaled long-acting antimuscarinic agonist; FEV1: forced expiratory volume in 1 second; DLCO: carbon monoxide diffusion capacity; FVC: forced vital capacity; PBMC: peripheral blood mononuclear cells; pred: predicted.