Intranasal Application of Budesonide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Nucleotide-Binding Oligomerization Domain-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation in Mice

Figure 3

Budesonide inhibited the infiltration of proinflammatory cells induced by LPS in mice. Twelve hours after the administration of LPS (5 mg/kg, i.t.), BALF was collected and the numbers of cells were counted, including total cells (a), macrophages (b), and neutrophils (c). The activity of MPO in lung tissue was detected to reflect neutrophil recruitment (d). The percentage of neutrophil and macrophages in the BALF (e). Data were expressed as deviations (). compared with the control group, compared with the ALI group, and compared with the ALI group.

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