Lymphocytic Choriomeningitis Virus Infection Demonstrates Higher Replicative Capacity and Decreased Antiviral Response in the First-Trimester Placenta
Innate immune responses are activated in term, but not in the first-trimester, human placental explants infected with LCMV. Term and the first-trimester placental explants were analyzed for mRNA expression by RT-PCR. (a) ifn-α, (b) il-6, (c) tnf-α, (d) ifn-γ, (e) il-28, and (f) il-29. Graph represents relative quantities and standard deviation of mRNA normalized to β-actin. Significance is defined as a value ≤ 0.05 comparing the first vs. third trimester, denoted by ( per group).