Research Article

Lymphocytic Choriomeningitis Virus Infection Demonstrates Higher Replicative Capacity and Decreased Antiviral Response in the First-Trimester Placenta

Table 1

ANOVA comparisons between the first-trimester and third-trimester explants.

ComparisonMean (relative expression or pg/mL) value

ifn-α
 Neg.1 vs. 10.999
 PolyI:C1.7 vs. 1.20.9777
 LCMV0.3 vs. 8.10.0002
ifn-γ
 Neg.1 vs. 10.999
 PolyI:C4.4 vs. 3.30.0178
 LCMV1.5 vs. 10.4358
il-6
 Neg.1 vs. 10.999
 PolyI:C3.6 vs. 42.4<0.0001
 LCMV0.8 vs. 16<0.0001
tnf-α
 Neg.1 vs. 10.999
 PolyI:C2.9 vs. 5.8<0.0001
 LCMV1.5 vs. 9.8<0.0001
il-28
 Neg.1 vs. 10.999
 PolyI:C5.8 vs. 10.6<0.0001
 LCMV0.8 vs. 0.70.999
il-29
 Neg.1 vs. 10.999
 PolyI:C12.6 vs. 15.8<0.0001
 LCMV1.9 vs. 2.90.2201
TNF-α protein
 Neg.1000 vs. 35360.11
 PolyI:C1000 vs. 12,604<0.0001
 LCMV1000 vs. 69830.0002
IL-6 protein
 Neg.1449 vs. 23,737<0.0001
 PolyI:C2386 vs. 50,633<0.0001
 LCMV2043 vs. 42,250<0.0001
IFN-γ protein
 Neg.0 vs. 00.9999
 PolyI:C0 vs. 414<0.0001
 LCMV0 vs. 15.3<0.0001