Research Article

Infiltration of Blood-Derived Macrophages Contributes to the Development of Diabetic Neuropathy

Figure 2

Hyperglycemia increases the microglia/macrophage activation in the spinal cord. (a–d) Photomicrographs show immunofluorescence of the microglia/macrophage marker CD11b in the spinal cord after STZ injection. for (a) and (b), 200 μm for (c) and (d). (e) Quantification of microglia/macrophage immunoreactivity showing a significant increase in CD11b expression during 4 weeks. Numbers of animals: control, ; D7, ; D14, ; D28, . Mann-Whitney test was used. Data are means SEMs; vs. control.
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