Clinical Correlations of Novel Autoantibodies in Patients with Dry Eye
Table 1
Demographic and clinical characteristics of patients according to novel autoantibody status.
Novel antibody positive ()
Novel antibody negative ()
value
Demographics
Age, years, mean (SD)
59.0 (10.5)
60.4 (12.4)
0.50
Female, n (%)
49 (87%)
66 (82%)
0.48
Dry eye-related symptoms, n (%)
Light sensitivity
22 (39%)
33 (41%)
0.86
Foreign body sensation/grittiness
39 (70%)
52 (65%)
0.58
Burning/tearing
27 (48%)
43 (54%)
0.60
Eye pain
18 (32%)
25 (31%)
0.99
Blurred vision
22 (39%)
30 (37%)
0.86
Dry eye measures, mean (SD)
Tear osmolarity (mOsm/L)
309 (22.6)
307 (14.6)
0.61
Schirmer test (mm)
6.6 (5.7)
8.5 (7.8)
0.27
Schirmer mm, n (%)
19 (63%)
20 (43%)
0.07
Total OSS (0-12)
6.4 (3.3)
6.0 (3.5)
0.56
Corneal staining (0-6)
2.7 (1.8)
2.5 (1.9)
0.57
Conjunctival staining (0-6)
3.7 (2.0)
3.6 (2.3)
0.74
,n (%)
35 (66%)
48 (67%)
0.94
mm or ,n (%)
42 (78%)
58 (76%)
0.84
SS-Related Symptoms, n (%)
Dry mouth
18 (32%)
24 (30%)
0.85
Joint/muscle pain
12 (21%)
12 (15%)
0.37
Fatigue
6 (11%)
10 (12%)
0.79
Autoimmune Diseases
Sjögren’s syndrome
9 (16%)
9 (11%)
0.41
Primary
8 (14%)
3 (4%)
0.051
Secondary
1 (2%)
6 (7%)
0.24
Other autoimmune diseases
10 (18%)
11 (14%)
0.57
SS diagnostic parameters
Anti-SSA
6 (11%)
7 (9%)
0.68
Anti-SSB
2 (4%)
3 (4%)
>0.99
RF
7 (13%)
7 (9%)
0.46
7 (13%)
7 (9%)
0.46
Positive biopsy
1/6 (17%)
1/7 (14%)
>0.99
Results are represented as mean (standard deviation) for continuous variables and number (percentage) for binary variables. The t-test was used for comparison of continuous variables and chi-squared testing for categorical variables between groups. SD: standard deviation; OSS: ocular staining score; SSA: Sjögren’s syndrome-related antigen A; SSB: Sjögren’s syndrome-related antigen B; RF: rheumatoid factor; ANA: antinuclear antibody.
