Clinical Correlations of Novel Autoantibodies in Patients with Dry Eye

Table 4

Multiple regression analysis demonstrating associations of antibody positivity with clinical parameters.

	Anti-SSA	Anti-SSB	RF	ANA	Anti-SP1	Anti-CA6	Anti-PSP
Tear osmolarity (mOsm/L)	1.0 (0.95-1.05)	1.6 (0.00-1.552E+83)	1.0 (0.98-1.07)	1.0 (0.95-1.03)	1.0 (0.96-1.03)	1.0 (0.96-1.03)	1.0 (0.99-1.05)
Schirmer test (mm)	1.2 (0.99-1.49)	0.3 (0.00-.)	0.7 (0.40-1.17)	1.1 (0.94-1.28)	1.1 (0.98-1.21)	0.9 (0.84-1.05)	0.9 (0.77-1.06)
Corneal staining (0-6)	0.8 (45-1.60)	2.1 (0.00-1358.86)	1.8 (0.97-3.29)	1.7 (1.04-2.65)	0.7 (0.49-1.02)	1.5 (1.20-1.97)	1.1 (0.80-1.46)
Conjunctival staining (0-6)	1.3 (0.68-2.49)	0.5 (0.06-4.63)	1.3 (0.83-1.97)	1.1 (0.78-1.63)	0.8 (0.62-1.06)	1.4 (1.04-1.76)	1.0 (0.77-1.29)
Total OSS (0-12)	1.0 (0.71-1.50)	0.83 (0.16-4.40)	1.3 (0.96-1.77)	1.2 (0.96-1.60)	0.8 (0.67-0.99)	1.3 (1.08-1.53)	1.0 (0.88-1.24)

Each clinical measure was analyzed in a separate logistic regression model including each antibody as the dependent variable and the clinical measure, age, sex, and other serologic markers as independent variables. Values represent hazard ratios and 95% confidence intervals. Bolded values represent . SSA: Sjögren’s syndrome-related antigen A; SSB: Sjögren’s syndrome-related antigen B; RF: rheumatoid factor; ANA: antinuclear antibody; SP1: salivary protein 1; CA6: carbonic anhydrase 6; PSP: parotid secretory antigen; OSS: ocular staining score.