Research Article
Analysis of Genetic Variation in CD40 and CD40L: Relationship with mRNA Relative Expression and Soluble Proteins in Acute Coronary Syndrome
Table 1
Clinical and demographic features of the CG and ACS patients.
(a) |
| | Variable | ACS median (IQR 25-75) | CG median (IQR 25-75) | Reference values | |
| | Age (years) | a | a | — | <0.001 | | Male/female ratio | 3.32 | 1.05 | — | <0.001 | | Cholesterol total (mg/dL) | 115 (93-139) | 162 (138-197) | 150-199 | <0.001 | | Glucose (mg/dL) | 125 (97-171) | 94 (82-118) | 75-105 | <0.001 | | Triglycerides (mg/dL) | 89 (72-108) | 99 (80-133) | <200 | <0.001 | | LDL-c (mg/dL) | 40 (33-52) | 68 (51-95) | <130 | <0.001 | | HDL-c (mg/dL) | 19 (13-26) | 37 (23-54) | >40 | <0.001 | | CRP (mg/L) | 19 (3.3-34.9) | 9.4 (8.2-11.8) | 1-10 | <0.001 | | Apo A-I (mg/dL) | 166 (148-184) | 197 (179-213) | 94-178 | <0.001 | | Apo B (mg/dL) | 132 (109-155) | 166 (147-186) | 63-133 | <0.001 | | CK (IU/mL) | 361 (147-1023) | N.A. | 24-195 | — | | CK-MB (IU/mL) | 48 (22-131) | N.A. | <12 | — | | Troponin I (ng/mL) | 3 (0.57-7.1) | N.A. | 0.1-0.4 | — |
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(b) |
| | Risk factor | ACS (%) | CG (%) | |
| | Obesity | 87 (27.2) | 35 (11.1) | <0.001 | | Diabetes mellitus type 2 | 148 (46.3) | 59 (18.7) | <0.001 | | Dyslipidemia | 140 (43.8) | 45 (14.2) | <0.001 | | High blood pressure | 214 (66.9) | 90 (28.5) | <0.001 | | Smoking | 159 (49.7) | 43 (13.6) | <0.001 |
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(c) |
| | ACS diagnosis | (%) | ACS treatment | (%) |
| | UA | 38 (11.9) | Acetyl salicylic acid | 304 (95) | | NSTEMI | 64 (20) | Statins | 291 (91) | | STEMI | 218 (68.1) | Antiplaquetary agents | 289 (90.3) | | | | Antihypertensive agents | 180 (56.2) | | | | Anticoagulants agents | 219 (68.3) | | | | Beta-blockers | 181 (56.6) | | | | Nitrates (isosorbide) | 69 (21.7) |
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Mann-Whitney test; ACS: acute coronary syndrome; Apo A-I: apolipoprotein A-I; Apo B: apolipoprotein B; CG: control group; CK: creatinine kinase; CK-MB: creatinine kinase muscle and brain; CRP: C-reactive protein; HDL-c: high-density lipoprotein; IQR: interquartile range; LDL-c: low-density lipoprotein; NSTEMI: non-ST-segment elevation myocardial infarction; N.A.: not applicable; UA: unstable angina; STEMI: ST-segment elevation myocardial infarction (STEMI). The data were expressed as a median and interquartile range (Q25-Q75) unless otherwise indicated. aData provided in . Age-dependent. |
