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Journal of Immunology Research
Volume 2019, Article ID 9406146, 10 pages
https://doi.org/10.1155/2019/9406146
Research Article

STAT3 Genotypic Variant rs744166 and Increased Tyrosine Phosphorylation of STAT3 in IL-23 Responsive Innate Lymphoid Cells during Pathogenesis of Crohn’s Disease

1Department of Medicine, University of Florida, Gainesville, FL 32610, USA
2Department of Surgery, University of Florida, Gainesville, FL 32610, USA
3Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
4Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA

Correspondence should be addressed to Sarah C. Glover; ude.lfu.enicidem@revolg.haras

Received 22 March 2019; Revised 17 May 2019; Accepted 27 May 2019; Published 19 June 2019

Guest Editor: Erwei Sun

Copyright © 2019 Ying Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. F. Neurath, “Current and emerging therapeutic targets for IBD,” Nature Reviews Gastroenterology & Hepatology, vol. 14, no. 5, pp. 269–278, 2017. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. Z. Zhang and Y. Y. Li, “Inflammatory bowel disease: pathogenesis,” World Journal of Gastroenterology, vol. 20, no. 1, pp. 91–99, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Boyapati, J. Satsangi, and G. T. Ho, “Pathogenesis of Crohn’s disease,” F1000Prime Reports, vol. 7, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. R. B. Sartor, “Mechanisms of disease: pathogenesis of Crohn’s disease and ulcerative colitis,” Nature Clinical Practice Gastroenterology & Hepatology, vol. 3, no. 7, pp. 390–407, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Huang and Z. Chen, “Inflammatory bowel disease related innate immunity and adaptive immunity,” American Journal of Translational Research, vol. 8, no. 6, pp. 2490–2497, 2016. View at Google Scholar
  6. A. Geremia, P. Biancheri, P. Allan, G. R. Corazza, and A. Di Sabatino, “Innate and adaptive immunity in inflammatory bowel disease,” Autoimmunity Reviews, vol. 13, no. 1, pp. 3–10, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Dai, M. Jiang, and M.-J. Sun, “Innate immunity and adaptive immunity in Crohn’s disease,” Annals of Translational Medicine, vol. 3, no. 3, pp. 34–34, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. C. S. N. Klose and D. Artis, “Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis,” Nature Immunology, vol. 17, no. 7, pp. 765–774, 2016. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Vivier, D. Artis, M. Colonna et al., “Innate lymphoid cells: 10 years on,” Cell, vol. 174, no. 5, pp. 1054–1066, 2018. View at Publisher · View at Google Scholar · View at Scopus
  10. G. F. Sonnenberg and D. Artis, “Innate lymphoid cells in the initiation, regulation and resolution of inflammation,” Nature Medicine, vol. 21, no. 7, pp. 698–708, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Diefenbach, “Innate lymphoid cells in the defense against infections,” European Journal of Microbiology & Immunology, vol. 3, no. 3, pp. 143–151, 2013. View at Publisher · View at Google Scholar
  12. M. Colonna, “Innate lymphoid cells: diversity, plasticity, and unique functions in immunity,” Immunity, vol. 48, no. 6, pp. 1104–1117, 2018. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Li, A. L. Doty, A. Iqbal, and S. C. Glover, “The differential frequency of Lineage(-)CRTH2(-)CD45(+)NKp44(-)CD117(-)CD127(+)ILC subset in the inflamed terminal ileum of patients with Crohn’s disease,” Cellular Immunology, vol. 304-305, pp. 63–68, 2016. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Forkel and J. Mjosberg, “Dysregulation of group 3 innate lymphoid cells in the pathogenesis of inflammatory bowel disease,” Current Allergy and Asthma Reports, vol. 16, no. 10, p. 73, 2016. View at Publisher · View at Google Scholar · View at Scopus
  15. J. H. Bernink, L. Krabbendam, K. Germar et al., “Interleukin-12 and -23 control plasticity of CD127(+) group 1 and group 3 innate lymphoid cells in the intestinal lamina propria,” Immunity, vol. 43, no. 1, pp. 146–160, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Geremia and C. V. Arancibia-Cárcamo, “Innate lymphoid cells in intestinal inflammation,” Frontiers in Immunology, vol. 8, pp. 1296–1296, 2017. View at Publisher · View at Google Scholar · View at Scopus
  17. UK IBD Genetics Consortium, J. C. Lee, D. Biasci et al., “Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn’s disease,” Nature Genetics, vol. 49, no. 2, pp. 262–268, 2017. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Zhang, J. Wu, X. Peng, J. Song, J. Wang, and W. Dong, “Associations between STAT3 rs744166 polymorphisms and susceptibility to ulcerative colitis and Crohn’s disease: a meta-analysis,” PLoS One, vol. 9, no. 10, article e109625, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. T. A. Willson, B. R. Kuhn, I. Jurickova et al., “STAT3 genotypic variation and cellular STAT3 activation and colon leukocyte recruitment in pediatric Crohn disease,” Journal of Pediatric Gastroenterology and Nutrition, vol. 55, no. 1, pp. 32–43, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Sugimoto, “Role of STAT3 in inflammatory bowel disease,” World Journal of Gastroenterology, vol. 14, no. 33, pp. 5110–5114, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Ciofani, A. Madar, C. Galan et al., “A validated regulatory network for Th17 cell specification,” Cell, vol. 151, no. 2, pp. 289–303, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. X. Guo, J. Qiu, T. Tu et al., “Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection,” Immunity, vol. 40, no. 1, pp. 25–39, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. L. C. Rankin, M. J. H. Girard-Madoux, C. Seillet et al., “Complementarity and redundancy of IL-22-producing innate lymphoid cells,” Nature Immunology, vol. 17, no. 2, pp. 179–186, 2016. View at Publisher · View at Google Scholar · View at Scopus
  24. O. . I. Koues, P. . L. Collins, M. Cella et al., “Distinct gene regulatory pathways for human innate versus adaptive lymphoid cells,” Cell, vol. 165, no. 5, pp. 1134–1146, 2016. View at Publisher · View at Google Scholar · View at Scopus
  25. N. Serafini, C. A. J. Vosshenrich, and J. P. Di Santo, “Transcriptional regulation of innate lymphoid cell fate,” Nature Reviews Immunology, vol. 15, no. 7, pp. 415–428, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. L. R. Ferguson, D. Y. Han, A. G. Fraser et al., “Genetic factors in chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn’s disease in a New Zealand population,” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 690, no. 1-2, pp. 108–115, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. G. Can, A. Tezel, H. Gurkan et al., “Investigation of IL23R, JAK2, and STAT3 gene polymorphisms and gene-gene interactions in Crohn’s disease and ulcerative colitis in a Turkish population,” The Turkish Journal of Gastroenterology, vol. 27, no. 6, pp. 525–536, 2016. View at Publisher · View at Google Scholar · View at Scopus
  28. G. Pickert, C. Neufert, M. Leppkes et al., “STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing,” The Journal of Experimental Medicine, vol. 206, no. 7, pp. 1465–1472, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. S. A. van de Pavert and E. Vivier, “Differentiation and function of group 3 innate lymphoid cells, from embryo to adult,” International Immunology, vol. 28, no. 1, pp. dxv052–dxv042, 2015. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Lapidus, O. Bernell, G. Hellers, and R. Lofberg, “Clinical course of colorectal Crohn’s disease: a 35-year follow-up study of 507 patients,” Gastroenterology, vol. 114, no. 6, pp. 1151–1160, 1998. View at Publisher · View at Google Scholar · View at Scopus
  31. L. C. S. De Vries, M. E. Wildenberg, W. J. De Jonge, and G. R. D’Haens, “The future of Janus kinase inhibitors in inflammatory bowel disease,” Journal of Crohn's and Colitis, vol. 11, no. 7, pp. 885–893, 2017. View at Publisher · View at Google Scholar · View at Scopus
  32. N. Li and R.-H. Shi, “Updated review on immune factors in pathogenesis of Crohn’s disease,” World Journal of Gastroenterology, vol. 24, no. 1, pp. 15–22, 2018. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Ignacio, C. N. S. Breda, and N. O. S. Camara, “Innate lymphoid cells in tissue homeostasis and diseases,” World Journal of Hepatology, vol. 9, no. 23, pp. 979–989, 2017. View at Publisher · View at Google Scholar · View at Scopus
  34. L. Chen, Z. He, E. Slinger et al., “IL-23 activates innate lymphoid cells to promote neonatal intestinal pathology,” Mucosal Immunology, vol. 8, no. 2, pp. 390–402, 2015. View at Publisher · View at Google Scholar · View at Scopus
  35. K. Mao, A. P. Baptista, S. Tamoutounour et al., “Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism,” Nature, vol. 554, no. 7691, pp. 255–259, 2018. View at Publisher · View at Google Scholar · View at Scopus