Autoimmune Hepatitis—Immunologically Triggered Liver Pathogenesis—Diagnostic and Therapeutic Strategies

Figure 2

Example of histological features of autoimmune hepatitis (a, b), virus hepatitis C (c, d), and drug-induced liver injury (DILI) (e, f). Haematoxylin and Eosin (H&E) staining: (a, c, e) 20-fold magnification; (b, d, f) 40-fold magnification. (a, b) Interface hepatitis. Liver biopsy histology of a patient with autoimmune hepatitis typically reveals a dense portal and periportal mononuclear cell infiltrate including several plasma cells. The infiltration of lymphocytes and plasma cells in the central and periportal areas reflecting interface hepatitis occurs during the acute phase of AIH but is rather not present during acute hepatitis caused by hepatitis C virus (c, d) and drug-induced liver injury (e, f).

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