A Multiple Antigen Peptide Vaccine Containing CD4⁺ T Cell Epitopes Enhances Humoral Immunity against Trichinella spiralis Infection in Mice

Figure 3

Serological antibody responses induced by immunization of MAP-TB or MAP-B measured by ELISA. (a) Specific IgG titers against B cell epitope peptide YX1 in the sera of mice immunized with MAP-TB or MAP-B on 0 w, 2 w, 4 w, 7 w, and 13 w. The total IgG is shown as the geometric mean titer of five mice within the group. indicates that anti-YX1 IgG titers in five mice immunized with MAP-TB were greatly elevated after the first immunization and were significantly higher than those in mice immunized with MAP-B or PBS (). (b, c) The OD₄₅₀ of subtype IgG1 and IgG2a responses in the sera of mice immunized with MAP-TB, MAP-B, or PBS at a dilution of 1 : 2,000 (b) and 1 : 5,000 (c). The values are shown as the . The data was shown as one representative experiment out of three.

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