Berberine Improves Inflammatory Responses of Diabetes Mellitus in Zucker Diabetic Fatty Rats and Insulin-Resistant HepG2 Cells through the PPM1B Pathway

Figure 10

Silenced PPM1B promoted glucose consumption and inflammatory cytokine levels and weakened glucose uptake capacity in HepG2-IR cells. (a) Glucose consumption of unit cell. (b) TNF-α levels. (c) IL-6 levels. (d) IL-1B levels. (e) IL-8 levels. (f) IL10 levels. (g) 2-NBDG uptake (2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose). The data are presented as of three independent experiments. ^▲ and ^▲▲, shRNA control group vs. shRNA PPM1B group; and , shRNA PPM1B+BBR group vs. shRNA PPM1B group; ^# and ^##, shRNA control+BBR group vs. shRNA control group. Magnification, ×100. Scale bar, 100 μm.

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