IL-17 Affects the Progression, Metastasis, and Recurrence of Laryngeal Cancer via the Inhibition of Apoptosis through Activation of the PI3K/AKT/FAS/FASL Pathways

Figure 4

The 200-17-induced FAS and FASL phosphorylation was dependent on PI3K/AKT pathway activation in the LC cell lines. (a) AKT, phosphorylation of AKT, phosphorylated FOXO3, FAS, and FASL, as well as the gray intensity analysis in Hep-2 cells, stimulated with 200-17 for 0.5 h, 1 h, 4 h, 6 h, and 8 h, following pretreatment with wortmannin for 0.5 h. (b) AKT, phosphorylation of AKT, phosphorylated FOXO3, FAS, and FASL, as well as the gray intensity analysis in Tu212 cells, stimulated with 200-17 for 0.5 h, 1 h, 4 h, 6 h, and 8 h, following pretreatment with wortmannin for 0.5 h. per group. One representative experiment of the three independent experiments is demonstrated. versus the control.

(a)

(b)