SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity

Figure 1

Induction of inflammation-driven colon carcinogenesis in mice. (a) Schematic of the CAC induction protocol used. WT () and Sirt5 KO () mice were injected with AOM on day 0. On day 5, mice were subjected to three 7-day cycles of 1.75% DSS in drinking water. Mice were sacrificed, and tumors were analyzed on day 75 after AOM injection. (b) Body weight changes of WT and Sirt5 KO mice over the whole process are shown as the . ; two-tailed unpaired -test. (c) Survival analysis of AOM/DSS-treated WT and Sirt5 KO mice. (d) The gene expression of SIRT5 in COAD (colon adenocarcinoma) samples and paired normal tissues (data from GEPIA2 website). (e) Overall survival plot of COAD patients with high or low expression of SIRT5 (data from GEPIA2 website).

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