Circulating Neutrophils of Nonalcoholic Steatohepatitis Patients Show an Activated Phenotype and Suppress T Lymphocytes Activity
PMN frequency of NASH patients correlate with liver damage. (a) Spearman correlation () between the frequency of freshly PMNs isolated from peripherical blood of NASH patients () and liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transferase (GGT) in serum (,, and , respectively), data derived from medical records of patients. value, ,,, and . (b–f) Boxplots represent the association between frequency calculated by flow cytometry analysis as a percentage of CD16high CD62Lhigh CD11bhigh of PMNs in NASH patients () and histological severity of liver disease evaluated by steatosis grade (b), inflammation grade (c), hepatocellular ballooning (d), fibrosis stage (e), and NAS activity score (f). All data are represented as . Each dot in the box-plot represents one subject/experiment (). Each subject has been studied in an independent experiment. Plots are representative for three independent experiments with one sample per experiment. Mann-Whitney unpaired test, 2-tailed. value, ,,,.
We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.