Research Article

Thymic Stromal Lymphopoietin Is Implicated in the Pathogenesis of Bullous Pemphigoid by Dendritic Cells

Figure 6

DC-SIGN-positive DCs were positive for TSLPR in the BP lesional skin, whereas langerin-positive LCs were not positive for TSLPR. (a) Staining with DC-SIGN (green), TSLPR (red), and DAPI (blue) showed the amount of DC-SIGN and TSLPR double-positive DCs (orange, white arrowhead) infiltrated in the dermis of the BP lesional skin. (b) Staining with langerin (green), TSLPR (red), and DAPI (blue) showed that all of langerin-positive LCs (green, white arrowhead) were negative for the TSLPR (red) expression. Results from three patients with BP are shown in (a, b), respectively. Dashed white lines indicate the basement membrane zone or edge of blister. Asterisks () indicate the area of blisters. Original magnification: ×200, . BP: bullous pemphigoid; DAPI: 4,6-diamino-2-phenyl indole; DCs: dendritic cells; DC-SIGN: dendritic cell–specific intercellular adhesion molecule-3-grabbing nonintegrin; LCs: Langerhans cells; TSLPR: thymic stromal lymphopoietin receptor.
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