Analysis of Killer Cell Immunoglobulin-Like Receptor Genes and Their HLA Ligands in Inflammatory Bowel Diseases
Table 1
Comparison between KIR and HLA gene frequencies in the IBD and control groups.
KIR alleles
UC, (%)
CD, (%)
Control, (%)
UC vs. control
Adj. a
Odds ratio (95% CI)
CD vs. control
Adj. a
Odds ratio (95% CI)
value
value
Inhibitory
2DL1
99 (99)
81 (98)
267 (97)
0.37
0.78
2.59 (0.3-21.3)
0.94
1
1.06 (0.2-5.2)
2DL2
64 (64)
55 (66)
167 (61)
0.59
0.98
1.14 (0.7-1.8)
0.38
1
1.25 (0.7-2.1)
2DL3
85 (85)
74 (83)
245 (89)
0.24
0.78
0.67 (0.3-1.3)
0.94
1
0.97 (0.4-2.1)
2DL4
100 (100)
83 (100)
274 (100)
—
—
—
—
—
—
2DL5
69 (69)
61 (73)
215 (78)
0.059
0.59
0.61 (0.4-1.1)
0.34
1
0.76 (0.4-1.3)
2DL5A
100 (100)
83 (100)
135 (49)
—
—
—
—
—
—
2DL5B
55 (55)
53 (64)
167 (61)
0.30
0.78
0.78 (0.5-1.2)
0.63
1
1.13 (0.7-1.9)
3DL1
90 (90)
74 (89)
254 (93)
0.39
0.78
0.71 (0.3-1.6)
0.29
1
0.64 (0.3-1.5)
3DL2
100 (100)
83 (100)
274 (100)
—
—
—
—
—
—
3DL3
100 (100)
83 (100)
274 (100)
—
—
—
—
—
—
Activating
2DS1
70 (70)
61 (73)
172 (63)
0.19
0.24
1.38 (0.8-2.2)
0.07
0.24
1.64 (0.9-2.8)
2DS2
67 (67)
55 (66)
173 (63)
0.49
0.49
1.18 (0.7-1.9)
0.60
0.63
1.14 (0.7-1.9)
2DS3
48 (48)
41 (49)
102 (37)
0.06
0.16
1.55 (0.9-2.5)
0.048
0.24
1.64 (1.0-2.7)
2DS4 (full)
19 (19)
21 (25)
84 (31)
0.02
0.14
0.53 (0.3-0.9)
0.35
0.63
0.76 (0.4-1.3)
2DS4 (var)
85 (85)
62 (75)
217 (79)
0.21
0.24
1.48 (0.8-2.7)
0.38
0.63
0.77 (0.4-1.4)
2DS5
47 (47)
33 (40)
101 (37)
0.07
0.16
1.51 (0.9-2.4)
0.63
0.63
1.13 (0.7-1.9)
3DS1
53 (53)
41 (49)
124 (45)
0.18
0.24
1.36 (0.8-2.1)
0.51
0.63
1.18 (0.7-1.9)
Pseudogene
2DP1
99 (99)
81 (98)
265 (97)
0.25
0.48
3.36 (0.4-26.8)
0.68
0.68
1.4 (0.3-6.5)
3DP1-1
24 (24)
18 (22)
80 (29)
0.32
0.48
0.76 (0.5-1.3)
0.18
0.68
0.67 (0.4-1.2)
3DP1-2
94 (100)
82 (99)
259 (95)
—
—
—
0.13
0.27
4.69 (0.6-36.5)
HLA alleles
HLA-C1Asn80
76 (76)
50 (60)
207 (76)
0.93
1
1.02 (0.6-1.7)
0.007
0.04
0.49 (0.3-0.8)
HLA-C2Lys80
66 (66)
57 (69)
200 (73)
0.18
0.36
0.71 (0.4-1.2)
0.44
0.52
0.81 (0.5-1.4)
HLA-B-Bw4Thr80
1 (1)
3 (4)
38 (14)
0.006
0.03
0.06 (0.008-0.4)
0.017
0.051
0.23 (0.07-0.77)
HLA-B-Bw4Ile80
53 (53)
51 (61)
149 (54)
0.81
1
0.94 (0.6-1.5)
0.25
0.37
1.34 (0.8-2.2)
HLA-A-Bw4-1
21 (21)
25 (30)
85 (31)
0.058
0.17
0.59 (0.3-1.0)
0.10
0.2
0.6 (0.4-1.1)
HLA-A-Bw4-2
96 (96)
76 (92)
274 (100)
—
—
—
—
—
—
aFDR-adjusted value for multiple testing using the Benjamini-Hochberg method. A value less than 0.05 was statistically significant. HLA: human leukocyte antigen; KIR: killer cell immunoglobulin-like receptor; IBD: inflammatory bowel disease; UC: ulcerative colitis; CD: celiac disease.
