Research Article
Analysis of Killer Cell Immunoglobulin-Like Receptor Genes and Their HLA Ligands in Inflammatory Bowel Diseases
Table 5
Inhibitory KIR (iKIR) genotypes in normal individuals and IBD patients.
| | HLA genotype | HLA gene/allele | Patients (%) | Control (%) | value | OR (95% CI) | | 2DL1 | 2DL2 | 2DL3 | 2DL4 | 2DL5 | 2DL5A | 2DL5B | 3DL1 | 3DL2 | 3DL3 |
| | Ulcerative colitis vs. control | | 1 | + | + | + | + | + | + | + | + | + | + | 28 (28%) | 59 (22%) | 0.19 | 1.41 (0.8-2.4) | | 2 | + | + | − | + | + | + | + | + | + | + | 8 (8%) | 11 (4%) | 0.12 | 2.08 (0.8-5.3) | | 3 | + | − | + | + | + | + | − | + | + | + | 12 (12%) | 44 (16%) | 0.33 | 0.71 (0.4-1.4) | | Crohn’s disease vs. control | | 1 | + | + | + | + | + | + | + | + | + | + | 26 (31%) | 59 (22%) | 0.07 | 1.82 (1.1-3.1) | | 2 | + | + | − | + | + | + | + | + | + | + | 7 (8%) | 11 (4%) | 0.12 | 2.17 (0.8-5.8) | | 3 | + | − | + | + | + | + | − | + | + | + | 12 (14%) | 44 (16%) | 0.69 | 0.87 (0.4-1.7) | | 4 | + | + | + | + | + | + | + | − | + | + | 7 (8%) | 10 (3.6%) | 0.08 | 2.40 (0.8-6.5) |
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A value less than 0.05 was statistically significant. Genotype frequency less than 2% is not included. |
