B7-H4 Inhibits the Development of Primary Sjögren’s Syndrome by Regulating Treg Differentiation in NOD/Ltj Mice
Blockade of B7-H4 increases proinflammatory cytokines in NOD/Ltj mice. (a–g) The salivary glands were collected from IgG isotype ctrl treatment and anti-B7-H4 mAb treatment NOD/Ltj mice. Relative levels of (a) IL-12 mRNA, (b) IL-6 mRNA, (c) IL-18 mRNA, (d) IL-1α mRNA, (e) TNF-α mRNA, (f) IFN-α mRNA, and (g) BAFF mRNA were determined by quantitative RT-PCR. Two-tailed Student’s -test. All the data presented were from three independent experiments.
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