The Role of MicroRNAs in Regulating Cytokines and Growth Factors in Coronary Artery Disease: The Ins and Outs

Table 1

miRNAs, cytokines and growth factors involved in the coronary artery disease.

	Increase in level				Decrease in level
	miRNA			Cytokine & growth factor	miRNA		Cytokine & growth factor
CAD	miR-1	miR-17-5p	miR-93	INF-γ	miR-10a	miR-29a/b	TGF-β
	miR-21	miR-133a-3p	miR-502	TNF-α	miR-17	miR-30e-5p
	miR-23a	miR-146a/b	miR-486	IL-1β	miR-19a	miR-92a/b
	miR-24	miR-191-3p	miR-454	IL-18	miR-22	miR-93-5p
	miR-25	miR-361-5p	miR-765	NogoB/Nus1	miR-23a	miR-126-5p
	miR-33a	miR-560-5p	miR-487a	IL-8	miR-31	miR-140-3p
	miR-34a	miR-574-5p	miR-221	TL1A/R	miR-126	miR-181d
	miR-92a	miR-615-5p	miR-222	Adamts5	miR-133	miR-199a
	miR-122	miR-313-5b	miR-223	CRP	miR-145	miR-195
	miR-133a	miR-370	miR-206		miR-147	miR-222
	miR-126	miR-106b	miR-340		miR-149	miR-342
	miR-134	miR-103a	miR-451		miR-150	miR-378
	miR-135	miR-199a	miR-624		miR-155	miR-424
	miR-191	miR-208a	miR-545		miR-182	miR-584
	miR-197	miR-502	miR-215		miR-720
	miR-2861
CA	miR-21	miR-99a		IL-1β	miR-100	miR-1181	—
	miR-92a	miR-370		IL-6, IL-9	miR-8059	miR-6816-3p
	miR-486-5p			TNF-α	miR-138-2-3p
UA	miR-320a	miR-92a	miR-1	IL-1β	miR-19a/b		IL-2
	miR-133a	miR-186	miR-126	IL-2, IL-8	miR-126		IL-4
	miR-208b	miR-210	miR-451	IL-9, IL-10	miR-132		IL-10
	miR-135a	miR-483	miR-486a	INF-γ	miR-147
	miR-140-3p	miR-499		IL-17 MCSF	miR-150
	miR-142-5p	miR-134a-5p		MCP-1
AMI	miR-208	miR-133a	miR-21	IL-6	miR-106		—
	miR-34a	miR-320a	miR-92a	IL-1Ra	miR-197
	miR-423	miR-486a	miR-1	TNF-α	miR-223
	miR-126	miR-126-5p	miR-133
	miR-29b	miR-145-3p	miR-192
	miR-194	miR-17-5p	miR-328
	miR-499
STEMI	miR-1			IL-2	miR-15a-5p	miR-320a	IL-6
	miR-30d			IL-6	miR-19a-5p	miR-134-5p
	miR-133			IL-8	miR-30e-5p	miR-25-5p
	miR-208			IL-10	miR-30a-5p	miR-16-5p
	miR-423				miR-101-3p	miR-183-5p
	miR-499				miR-101-5p	miR-10a
					miR-328-5p	miR-107
					miR-744-5p	miR-375
					miR-103a-3p
					miR-1307-5p
					miR-409-5p
					miR-181b-5p
					miR-181a-5p

CAD: coronary artery disease; CA: coronary atherosclerosis; UA: unstable angina; AMI: acute myocardial infarction; STEMI: ST-segment elevated myocardial infarction; Ra: receptor antagonist; MCSF: macrophage colony-stimulating factor; MCP-1: monocyte chemoattractant protein-1; INF-γ: interferon-gamma, TNF-α: tumor necrosis factor-alpha; IL: interleukin; CRP: C-reactive protein.