Inflammation Is Associated with Worse Outcome in the Whole Cohort but with Better Outcome in Triple-Negative Subtype of Breast Cancer Patients
Association between the inflammatory pathway score and tumor aggressiveness by the subtypes. (a) Boxplots of the inflammatory scores by Nottingham pathological grade in triple-negative breast cancer (TNBC), estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2-), and HER2-positive subtypes of the METABRIC and TCGA breast cancer cohorts. Tukey-type boxplots show median and interquartile level values, and the ANOVA test was used to calculate values. (b) Tumors with low (blue) and high (red) inflammatory scores in both cohorts of patients with each subgroup are compared for survival DSS, DFS, and OS of inflammatory score high and low inflammatory groups in each breast cancer subtype of METABRIC cohort. Log-rank test used to calculate values to compare two groups with Kaplan-Meier survival curves.
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