TY - JOUR A2 - Sautto, Giuseppe A. AU - Baucells, Andrés AU - Martínez, Maria Angeles AU - Alvarado-Cardenas, Marcelo AU - Mariscal, Anaís AU - Martinez-Martinez, Laura AU - Juárez, Cándido AU - Selva-O’Callaghan, Albert PY - 2020 DA - 2020/07/16 TI - Anti-HMGCR Specificity of HALIP: A Confirmatory Study SP - 6292631 VL - 2020 AB - A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern). In this study, we furthered the original studies to demonstrate the association of anti-HMGCR antibodies with the HALIP. Human anti-HMGCR antibodies from patients’ sera were purified and incubated with rat triple tissue (kidney/stomach/liver). A characteristic HALIP was observed. Additionally, a colocalization assay of human anti-HMGCR antibodies with rabbit polyclonal anti-HMGCR antibodies showed colocalization of both immunofluorescence patterns. This study confirms that the HALIP is due to human anti-HMGCR antibodies. SN - 2314-8861 UR - https://doi.org/10.1155/2020/6292631 DO - 10.1155/2020/6292631 JF - Journal of Immunology Research PB - Hindawi KW - ER -