Review Article
Is there a Role of Intravenous Immunoglobulin in Immunologic Recurrent Pregnancy Loss?
Table 1
Possible mechanisms of intravenous immunoglobulin (IVIg) in the prevention of recurrent pregnancy loss (RPL).
| | Mechanism |
| IVIg | Reduce autoantibodies | Neutralize autoantibodies | Decrease NK cell activity | Control the secretion of cytokines | Suppress the binding and activation of complement | Modulate and blockade of Fc receptor | Inhibit FcγRIIb signaling in macrophages | Increase the clearance of pathogenic antibody by FcRn | Suppress superantigens | Regulate adhesion molecules on B- and T lymphocytes | Increase apoptosis of activated cytotoxic lymphocytes | Anti-idiotypic modulation | Apoptotic mechanisms | Formation of immune complexes |
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