Review Article

Is there a Role of Intravenous Immunoglobulin in Immunologic Recurrent Pregnancy Loss?

Table 1

Possible mechanisms of intravenous immunoglobulin (IVIg) in the prevention of recurrent pregnancy loss (RPL).

Mechanism

IVIgReduce autoantibodies
Neutralize autoantibodies
Decrease NK cell activity
Control the secretion of cytokines
Suppress the binding and activation of complement
Modulate and blockade of Fc receptor
Inhibit FcγRIIb signaling in macrophages
Increase the clearance of pathogenic antibody by FcRn
Suppress superantigens
Regulate adhesion molecules on B- and T lymphocytes
Increase apoptosis of activated cytotoxic lymphocytes
Anti-idiotypic modulation
Apoptotic mechanisms
Formation of immune complexes